Amoxicrid Retard 150 mg/ml Injection – Long-Acting Antibiotic for Livestock & Pets

Amoxicillin is a semi-synthetic broad-spectrum penicillin that is bactericidal in vitro against a wide range of Gram-positive and Gram-negative bacteria.

The product is indicated for the treatment of infections caused by amoxicillin-susceptible organisms in cattle, sheep, pigs, dogs and cats where a prolonged period of antibiotic activity is required from a single administration. It can be used for the treatment and control of secondary bacterial infections where bacteria are not the primary cause of the infections.

COMPOSITION
Amoxicillin (as amoxicillin trihydrate)………. 150 mg/ml

INDICATIONS
Amoxicillin is a semi-synthetic broad-spectrum penicillin that is bactericidal in vitro against a wide range of Gram-positive and Gram-negative bacteria.

Gram-positive

Actinomyces bovis, Bacillus anthracis, Clostridium spp., Erysipelothrix rhusiopathiae, Corynebacterium spp., Peptostreptococcus spp., Staphylococcus spp. (beta-lactamase-non-producing strains), Streptococcus spp.

Gram-negative

Actinobacillus lignierisi, Actinobacillus pleuropneumoniae, Actinobacillus equili, Bacteroides spp., Bordetella bronchiseptica, Campylobacter spp., Escherichia coli (beta-lactamase-non-producing strains), Fusobacterium necrophorum, Haemophillus spp., Klebsiella spp., Pasteurella spp., Proteus mirabilis (beta-lactamase-non-producing strains).

The product is indicated for the treatment of infections caused by amoxicillin-susceptible organisms in cattle, sheep, pigs, dogs and cats where a prolonged period of antibiotic activity is required with a single administration. It can be used for the treatment and control of secondary bacterial infections when the bacteria are not the primary cause of the infections.

Indications for Amoxicrid Retard Inj:

Infections of the digestive tract including enteritis.
Infections of the respiratory tract including pneumonia in fattening bulls.
Infections of the urogenital tract including cystitis and metritis.
Infections of the skin and connective tissue including abscesses and wounds, foot and joint infections.
Prevention of post-operative infections by administering the product pre-operatively.
CONTRAINDICATIONS
Do not use in case of hypersensitivity to the active substance or to any of the excipients.

Like other penicillins, amoxicillin should not be administered orally or parenterally to rabbits, guinea pigs and hamsters. It should be used with caution in other small herbivores. It should not be administered intravenously or intra-articularly.

ADVERSE REACTIONS
Occasionally, the product may cause reactions at the inoculation site.

DOSAGE FOR EACH SPECIES, ROUTE AND METHOD OF ADMINISTRATION
Can be administered subcutaneously or intramuscularly.

The recommended dose is 15 mg/s.a./kg body weight, which is equivalent to 1 ml of product /10 kg body weight. This dose can be repeated after 48 hours.

The following table provides an example of dosage in different species:

To ensure a correct dose, the body weight of the animals should be accurately determined, whenever possible, to avoid underdosing.

RECOMMENDATIONS ON CORRECT ADMINISTRATION
To avoid underdosing, it is recommended to weigh the animal before administering the veterinary medicinal product. Shake the bottle well before use. This product does not contain antimicrobial preservatives. Wipe the septum before removing each dose from the bottle. Use dry, sterile syringes and needles. In cattle, no more than 20 ml should be administered at a single injection site.

WITHDRAWAL PERIODS
Cattle (meat and offal): 92 days.

Sheep (meat and offal): 45 days.

Pigs (meat and offal): 93 days.

Cattle milk: 9 days (18 milkings, 216 hours).

Sheep milk: 6.5 days (13 milkings, 156 hours).

SPECIAL STORAGE PRECAUTIONS
Do not store above 25°C.

Protect from light.

SHELF LIFE
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.

Shelf life after first opening the immediate packaging: 28 days.

SPECIAL WARNINGS
Special precautions for use in animals

The use of the product should be based on susceptibility testing of bacteria isolated from animals. If this is not possible, therapy should be based on local epidemiological information on the susceptibility of the target bacteria. Use of the product deviating from the instructions provided in the SPC may increase the prevalence of resistant bacteria and may decrease the effectiveness of treatment due to the potential for cross-resistance. Official and local antimicrobial policies should be taken into account when using the product.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

People with known hypersensitivity to amoxicillin should avoid contact with the veterinary medicinal product.

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-reactions to cephalosporins and vice versa. Allergic reactions to these substances can sometimes be severe. Do not handle this product if you know you are sensitive or if you have been advised not to work with such substances. Handle this product with great care to avoid exposure, taking all necessary precautions. Swelling of the face, lips or eyes or difficulty breathing are more serious symptoms which require urgent medical attention.

Use during pregnancy, lactation or lay

The product can be used in pregnant or lactating animals.

Interactions with other medicinal products or other forms of interaction

None known.

Overdose (symptoms, emergency procedures, antidotes), if applicable

Amoxicillin has low toxicity and is well tolerated when administered parenterally. With the exception of occasional local reactions at the site of administration, which may occur even at the recommended dose, no other adverse effects have been observed even in the event of accidental overdose.

Incompatibilities

In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR WASTE MATERIALS, IF ANY

Medicinal products should not be disposed of via wastewater or household waste. Ask your veterinarian for information on how to dispose of medicines no longer required. These measures will help to protect the environment.

PACKAGING/ PACKAGING
250 ml bottle.